Glasinovic J C, Delage Y, Erlinger S
Biomedicine. 1976 Sep 30;25(7):255-8.
131I-labeled BSP is obtained by the incorporation of one molecule of radioactive iodine in BSP. The purpose of this work was to study the influence of the added iodine on the hepatic extraction and biliary excretion of BSP. Two types of experiments were performed. In the first, a compartmental analysis of BSP and 131I-labeled BSP disappearance curves was performed after the simultaneous injection of 5 mg per kg of b. wt. of BSP and 10 muCi of 131I-labeled BSP: both, the plasma to liver and liver to bile transfer rates were significantly lower for 131I-labeled BSP than for BSP; the liver to plasma transfer rates were not significantly different. In the second series of experiments, the hepatic uptake of BSP and 131I-labeled BSP was estimated by the multiple indicator dilution technique: the extraction of BSP (59% +/- SD 5) was significantly higher than that of 131I-labeled BSP (35% +/- SD 5) (P less than 0.001). In conclusion the labeling of BSP with 131I significantly modified the hepatic handling of the dye; 131I-labeled BSP cannot therefore be used as a tracer of BSP.
131I标记的磺溴酞钠（BSP）是通过将一分子放射性碘掺入BSP中获得的。这项工作的目的是研究添加的碘对BSP肝摄取和胆汁排泄的影响。进行了两种类型的实验。在第一个实验中，在每千克体重注射5毫克BSP和10微居里131I标记的BSP后，对BSP和131I标记的BSP消失曲线进行了房室分析：131I标记的BSP的血浆到肝脏以及肝脏到胆汁的转运速率均显著低于BSP；肝脏到血浆的转运速率无显著差异。在第二系列实验中，通过多指示剂稀释技术估计了BSP和131I标记的BSP的肝摄取：BSP的摄取率（59%±标准差5）显著高于131I标记的BSP（35%±标准差5）（P小于0.001）。总之，用131I标记BSP显著改变了染料的肝脏处理方式；因此，131I标记的BSP不能用作BSP的示踪剂。
