Kybal J, Vlcek V
Biotechnol Bioeng. 1976 Dec;18(12):1713-8. doi: 10.1002/bit.260181206.
A new device is designed that is suitable for both laboratory- and industrial-scale cultivation of microorganisms, particularly filamentous fungi, on the surface of liquid media. The device reliably ensures the sterility of cultivation, regardless of its duration. Its installation costs are relatively low and maximum production is reached per unit of installation space. In comparison with submerged cultures in fermentors, the proposed mode does not use a high consumption of energy for stirring and aeration (consequently, the duration of cultivation is not an economically relevant factor) and does not require maintenance of complicated equipment. Due to the building and construction of the technological equipment, the production plant is capable of very fast expansion and, when the need arises of very fast and economical liquidation.
设计了一种新装置，适用于在液体培养基表面对微生物，特别是丝状真菌进行实验室规模和工业规模的培养。该装置可靠地确保培养的无菌性，无论培养持续时间长短。其安装成本相对较低，每单位安装空间可实现最大产量。与发酵罐中的深层培养相比，该提议模式在搅拌和通气方面不消耗大量能源（因此，培养持续时间不是经济相关因素），也不需要维护复杂的设备。由于工艺设备的构建，生产工厂能够非常快速地扩张，并且在需要时能够非常快速且经济地清算。
