阿莫西林治疗氯霉素血液学禁忌患者的伤寒热。
Amoxycillin in treatment of typhoid fever in patients with haematological contraindications to chloramphenicol.
作者信息
Afifi A M, Adnan M, El Garf A A
出版信息
Br Med J. 1976 Oct 30;2(6043):1033-4. doi: 10.1136/bmj.2.6043.1033.
Thirty adults with proved typhoid fever were treated with amoxycillin 1 g six-hourly by mouth for an average of 14 days because of haematological contraindications to chloramphenicol. Eighteen patients were Egyptian men with the Mediterranean variety of glucose-6-phosphate dehydrogenase deficiency and an enzyme activity in the red cells fanging from 0 to 3%, and 12 patients had a history of severe but reversible myelosuppression after eight to 12 days' treatment with chloramphenicol 1-5-2 g daily. The clinical and bacteriological responses in this group of patients were compared with those of 30 haematologically normal patients of comparable age and sex treated with chloramphenicol. The results showed that amoxycillin is an effective alternative to chloramphenicol for treating typhoid fever in patients with haematological contraindications to chloramphenicol.
由于存在氯霉素血液学禁忌证，30名确诊为伤寒热的成年人接受阿莫西林治疗，口服剂量为1克，每6小时一次，平均治疗14天。18名患者为患有地中海型葡萄糖-6-磷酸脱氢酶缺乏症的埃及男性，红细胞中的酶活性为0%至3%，12名患者在每日使用1.5 - 2克氯霉素治疗8至12天后有严重但可逆的骨髓抑制病史。将该组患者的临床和细菌学反应与30名年龄和性别相仿、血液学正常且接受氯霉素治疗的患者进行比较。结果表明，对于有氯霉素血液学禁忌证的患者，阿莫西林是治疗伤寒热的有效替代药物。
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