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B组和D组链球菌R质粒之间的分子研究及可能的相关性

Molecular studies and possible relatedness between R plasmids from groups B and D streptococci.

作者信息

El-Solh N, Bouanchaud D H, Horodniceanu T, Roussel A, Chabbert Y A

出版信息

Antimicrob Agents Chemother. 1978 Jul;14(1):19-23. doi: 10.1128/AAC.14.1.19.

Abstract

Resistance plasmids isolated from Streptococcus agalactiae (group B) and S. faecalis (group D) have been compared in regard to resistance markers, molecular weight, and DNA-DNA homology. Three of them (pIP501, pIP612, and pIP613) have been found to confer identical (or very similar) resistance patterns (erythromycin, lincomycin, and streptogramin B, respectively) and to have similar molecular weights (19.8 x 10(6), 22.7 x 10(6), and 17.6 x 10(6), respectively) and a high level of DNA-DNA homology in hybridization experiments (90 to 100%). These results are compatible with the view that these plasmids may derive from one common ancestor, and/or that they can be transferred between unrelated Streptococcus strains belonging to the same or different groups.

摘要

已对从无乳链球菌(B组)和粪肠球菌(D组)分离出的耐药质粒在耐药标记、分子量和DNA-DNA同源性方面进行了比较。已发现其中三个(pIP501、pIP612和pIP613)具有相同(或非常相似)的耐药模式(分别为红霉素、林可霉素和链阳菌素B),分子量相似(分别为19.8×10⁶、22.7×10⁶和17.6×10⁶),并且在杂交实验中具有高水平的DNA-DNA同源性(90%至100%)。这些结果与以下观点相符:这些质粒可能源自一个共同祖先,和/或它们可以在属于相同或不同组的不相关链球菌菌株之间转移。

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N Engl J Med. 1968 Mar 7;278(10):538-40. doi: 10.1056/NEJM196803072781005.
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