一名库欣综合征患者对地塞米松反应的差异。
Variation in response to dexamethasone of a patient with Cushing's syndrome.
作者信息
Rorstad O, Urtasun R, Watanabe M
出版信息
Can Med Assoc J. 1976 Nov 6;115(9):878-9.
Abstract
A patient with Cushing's syndrome due to a nonresectable chromophobe adenoma underwent external irradiation of the hypothalamic-pituitary area. The signs of Cushing's syndrome ameliorated subsequently but recurred eventually, necessitating bilateral adrenalectomy 30 months after initial presentation. Response to dexamethasone suppression testing on four occasions varied greatly. These results may reflect alterations in sensitivity of the tumour or the hypothalamic-pituitary axis to feedback inhibition by glucocorticoids.
摘要
一名因不可切除的嫌色细胞瘤导致库欣综合征的患者接受了下丘脑 - 垂体区域的外照射。库欣综合征的体征随后有所改善，但最终复发，在初次就诊30个月后需要进行双侧肾上腺切除术。四次地塞米松抑制试验的反应差异很大。这些结果可能反映了肿瘤或下丘脑 - 垂体轴对糖皮质激素反馈抑制的敏感性变化。
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本文引用的文献
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Clinical application of a new test of pituitary reserve.垂体储备新检测方法的临床应用
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Failure of dexamethasone suppression test to indicate bilateral adrenocortical hyperplasia in Cushing's syndrome.地塞米松抑制试验未能提示库欣综合征患者存在双侧肾上腺皮质增生。
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Cushing's disease with cure by resection of a pituitary adenoma. Evidence against a primary hypothalamic defect.通过切除垂体腺瘤治愈的库欣病。反对原发性下丘脑缺陷的证据。
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Inhibition of adrenocorticotropic hormone production by glucocorticoids in mouse pituitary tumor cells.糖皮质激素对小鼠垂体肿瘤细胞促肾上腺皮质激素分泌的抑制作用。
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Cushing's disease with periodic hormonogenesis: one explanation for paradoxical response to dexamethasone.伴有周期性激素生成的库欣病：对地塞米松矛盾反应的一种解释
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ACTH synthesis and release in pituitary monolayer culture: effect of dexamethasone.垂体单层培养中促肾上腺皮质激素（ACTH）的合成与释放：地塞米松的作用
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