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An improved synthesis of 1-0-[3H] alkyl-2-acyl-sn-glycerol-3-phosphorylethanolamine with an unsaturated acyl chain.

作者信息

Paltauf F

出版信息

Chem Phys Lipids. 1976 Oct;17(2-3 SPEC NO):148-54. doi: 10.1016/0009-3084(76)90058-x.

DOI:10.1016/0009-3084(76)90058-x
PMID:991375
Abstract

A method is described for the synthesis of 1-0-[9', 10'-(3)H2] octadecyl-2-octadecenoyl-sn-glycerol-3-phosphorylethanol-amine, starting from rac 1-0-octadecen-9'-ylglycerol. The sn-1-alkyl enantiomer is obtained by an enzymatic reaction involving deacylation of rac 1-0-octadecen-9'-yl-2-octadecenoyl-glycerol-3-phosphoryl-N-(tert.-butyloxycarbonyl) ethanolamine with phospholipase A2. The resulting lyso compound is tritiated with 3H2 in the presence of platinum catalyst and reacylated with oleoyl anhydride to yield the final product.

摘要

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引用本文的文献

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J Am Oil Chem Soc. 1978 Apr;55(4):422-7. doi: 10.1007/BF02911905.