Cope A P
The Kennedy Institute of Rheumatology Immunology Division 1 Aspenlea Road Hammersmith London W6 8LH UK.
Curr Opin Immunol. 1998 Dec;10(6):669-76. doi: 10.1016/s0952-7915(98)80087-3.
Studies extending over a decade have provided compelling evidence to suggest that chronic expression of proinflammatory cytokines in vivo leads to unique regulatory properties that target the cognate immune response in a way that appears to be beneficial to the host. This review focuses on the prototypic proinflammatory cytokine tumour necrosis factor alpha, because recent studies of autoimmune disease in mice and man have unraveled a novel and unexpected immunosuppressive role for this inflammatory mediator during the effector phase of the autoimmune process. So far, T lymphocytes would appear to be important cellular targets of this immunoregulatory effect.
长达十年的研究提供了令人信服的证据，表明体内促炎细胞因子的慢性表达会导致独特的调节特性，以一种似乎对宿主有益的方式靶向同源免疫反应。本综述聚焦于典型的促炎细胞因子肿瘤坏死因子α，因为最近对小鼠和人类自身免疫性疾病的研究揭示了这种炎症介质在自身免疫过程效应阶段的一种新的、意想不到的免疫抑制作用。到目前为止，T淋巴细胞似乎是这种免疫调节作用的重要细胞靶点。
