Pelley R J, Bukowski R M
Department of Hematology and Medical Oncology, Cleveland Clinic Foundation, Ohio 44195, USA.
Curr Opin Oncol. 1999 Jan;11(1):32-7. doi: 10.1097/00001622-199901000-00008.
Neuroendocrine tumors of the gastrointestinal tract are rare tumors which can be classified as amine precursor uptake and decarboxylation tumors (APU-Domas). Although the majority of clinically apparent tumors are malignant, they are frequently slow growing. Despite this characteristic, they may generate disabling hormonal syndromes requiring aggressive treatment to achieve palliation. Recent advances in understanding the pathophysiology of these tumors has led to better medical therapy with chemotherapeutic agents, somatostatin analogues, and biologic therapies. This review will update the recent efforts in systemic therapies of the gastrointestinal neuroendocrine tumors.
胃肠道神经内分泌肿瘤是罕见肿瘤，可归类为胺前体摄取与脱羧细胞瘤（APUD瘤）。尽管大多数临床可见的肿瘤是恶性的，但它们通常生长缓慢。尽管有这一特征，但它们可能引发导致功能障碍的激素综合征，需要积极治疗以实现姑息治疗。最近在理解这些肿瘤病理生理学方面的进展已带来了更好的药物治疗，包括化疗药物、生长抑素类似物和生物疗法。本综述将更新胃肠道神经内分泌肿瘤全身治疗的最新进展。
