Glyoxalase I activity in human prostate cancer: a potential marker and importance in chemotherapy.

PURPOSE

To provide information on the activity of Gly-I in prostate cancer.

MATERIALS AND METHODS

We performed qualitative Gly-I assay on prostate tissues.

RESULTS

Gly-I activity between prostate cancer and noncancerous specimens differed substantially and significantly, although such activity also varied somewhat among cancer specimens.

CONCLUSIONS

Gly-I activity is indeed higher in cancerous than in noncancerous specimens, suggesting that it may play a role in prostate cancer homeostasis and survival.