Arck P, Dietl J, Clark D
Charité, Campus Virchow Klinikum, Humbolt University, 13353 Berlin, Germany.
Biol Reprod. 1999 Feb;60(2):227-33. doi: 10.1095/biolreprod60.2.227.
The mammalian fetus has been perceived, paradoxically, as a successful allograft, a successful tumor, and a successful parasite. Success depends on fetal trophoblast cells, which form the interface with the mother. The maternal immune system is involved in the success of pregnancy and in its failure. The discovery that maternal gammadelta T cells may recognize and react to the fetal trophoblast and the definition of a vascular mechanism whereby their Th1 and Th2/3-type cytokines may abort embryos replaces confusion and debate with a new and simple clarity that enables further research.
矛盾的是,哺乳动物胎儿被视为成功的同种异体移植物、成功的肿瘤和成功的寄生虫。成功取决于胎儿滋养层细胞,它们构成了与母体的界面。母体免疫系统既关乎妊娠的成功,也关乎其失败。母体γδ T细胞可能识别胎儿滋养层并对其作出反应这一发现,以及一种血管机制的确定(通过该机制,它们的Th1和Th2/3型细胞因子可能导致胚胎流产),用一种新的、简单明了的认识取代了混乱和争论,这使得进一步的研究成为可能。