成人急性白血病的异基因骨髓移植
Allogeneic bone marrow transplantation for acute leukemia in adults.
作者信息
Masszi T, Reményi P, Kriván G, Goda V, Réti M
机构信息
Bone Marrow Transplantation Unit, St. László Hospital, Budapest, Hungary.
出版信息
Bone Marrow Transplant. 1998 Dec;22 Suppl 4:S77-9.
From September 1993 to August 1997, 24 consecutive adult acute leukemia patients (20 AML and 4 ALL) received allogeneic bone marrow transplant (21 sibling, 1 twin, 2 MUD). The probability of 3 year leukemia free survival is 19/24 (79%), the transplant related mortality is 2/24 (8%), the relapse rate is 3/24 (13%). The median follow up period is 34 months (range 7-51). Three AML patients with high probability of TRM received a special radiation-free conditioning regimen (mitobronitol/cytarabine/ cyclophosphamide) originally described by Kelemen et al in CML patients for decreasing transplant related complications. All the three patients are alive and disease free over 3 years.
1993年9月至1997年8月，连续24例成年急性白血病患者（20例急性髓系白血病和4例急性淋巴细胞白血病）接受了异基因骨髓移植（21例同胞供者，1例双胞胎供者，2例无关供者）。3年无白血病生存率为19/24（79%），移植相关死亡率为2/24（8%），复发率为3/24（13%）。中位随访期为34个月（范围7 - 51个月）。3例移植相关死亡率高的急性髓系白血病患者接受了一种特殊的无放疗预处理方案（米托布醇/阿糖胞苷/环磷酰胺），该方案最初由凯莱门等人描述用于慢性粒细胞白血病患者以降低移植相关并发症。所有这3例患者均存活且3年无病。
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