Brabant M C, Fristrom D, Bunch T A, Baker S E, Brower D L
Department of Molecular and Cellular Biology, University of Arizona, Tucson 85721, USA.
Ann N Y Acad Sci. 1998 Oct 23;857:99-109. doi: 10.1111/j.1749-6632.1998.tb10110.x.
The PS1 and PS2 integrins are required for morphogenesis of the adult Drosophila wing. Clonal analysis experiments have shown that both integrins are necessary to maintain adhesion between the dorsal and ventral wing epithelia. We have found that early in wing morphogenesis, the integrins are also required for a regulatory event, and this may explain why PS1 and PS2 must be expressed on opposite surfaces of the wing at the onset of pupariation. Overexpression of integrin subunits during this early phase can lead to separation of dorsal and ventral surfaces, and we present evidence here that this dominant phenotype (the Blistermaker phenotype) results from a gain of integrin function, as opposed to negative interference from free integrin subunits. A possible model for an integrin signaling requirement in the wing is discussed.
PS1和PS2整合素是成年果蝇翅膀形态发生所必需的。克隆分析实验表明，这两种整合素对于维持翅膀背腹上皮之间的黏附是必要的。我们发现，在翅膀形态发生早期，整合素对于一个调控事件也是必需的，这或许可以解释为什么在化蛹开始时PS1和PS2必须在翅膀的相对表面表达。在此早期阶段过表达整合素亚基会导致背腹表面分离，我们在此提供证据表明这种显性表型（水泡制造者表型）是整合素功能获得的结果，而不是来自游离整合素亚基的负性干扰。文中讨论了翅膀中整合素信号需求的一个可能模型。
