Miyamoto S, Katz B Z, Lafrenie R M, Yamada K M
Craniofacial Developmental Biology and Regeneration Branch, National Institutes of Health, Bethesda, Maryland 20892-4370, USA.
Ann N Y Acad Sci. 1998 Oct 23;857:119-29. doi: 10.1111/j.1749-6632.1998.tb10112.x.
Fibronectin and integrins play crucial roles in a variety of morphogenetic processes, in which they mediate cell adhesion, migration, and signal transduction. They induce hierarchical transmembrane organization of cytoskeletal and signaling molecules into multimolecular complexes of more than 30 proteins. Organization of these complexes is a synergistic process dependent on integrin aggregation and occupancy, as well as tyrosine phosphorylation. Integrins also cooperate with growth-factor receptors to enhance signaling. Fibronectin and integrins induce a variety of downstream effects, including enhanced transcription factor activity, induction of over 30 genes (> half novel), and altered expression of over 100 proteins. Fibronectin and integrins therefore trigger a hierarchy of signaling responses involved in regulating processes crucial for normal morphogenesis, including cell adhesion, migration, and specific gene expression.
纤连蛋白和整合素在多种形态发生过程中发挥着关键作用，在这些过程中它们介导细胞黏附、迁移和信号转导。它们诱导细胞骨架和信号分子进行分层跨膜组织，形成由30多种蛋白质组成的多分子复合物。这些复合物的组织是一个协同过程，依赖于整合素的聚集和占据以及酪氨酸磷酸化。整合素还与生长因子受体协同作用以增强信号传导。纤连蛋白和整合素诱导多种下游效应，包括增强转录因子活性、诱导30多个基因（超过一半是新基因）以及改变100多种蛋白质的表达。因此，纤连蛋白和整合素触发了一系列信号反应，这些反应参与调节对正常形态发生至关重要的过程，包括细胞黏附、迁移和特定基因表达。
