Horton R W, Meldrum B S, Sawaya M C, Stephenson J D
Eur J Pharmacol. 1976 Nov;40(1):101-6. doi: 10.1016/0014-2999(76)90359-9.
Two clinically effective anticonvulsants, phenobarbitone and diazepam, protected 5-day old chicks against picrotoxin convulsions without reducing brain GABA-transaminase activity or raising brain GABA concentration. Ethanolamine-O-sulphate and amino-oxyacetic acid, in doses which inhibited GABA-transminase by at least 63% and approximately doubled brain GABA concentration, did not significantly affect the ED50 for picrotoxin convulsions. The ED50 for picrotoxin convulsions was significantly raised by di-n-propylacetate (800 mg/kg) which inhibited GABA transaminase activity by 6% and elevated brain GABA concentration by 26%.
两种临床有效的抗惊厥药，苯巴比妥和地西泮，可保护5日龄雏鸡免受印防己毒素惊厥的影响，且不降低脑γ-氨基丁酸转氨酶活性或提高脑γ-氨基丁酸浓度。乙醇胺-O-硫酸盐和氨氧基乙酸，在至少抑制γ-氨基丁酸转氨酶63%并使脑γ-氨基丁酸浓度增加约一倍的剂量下，对印防己毒素惊厥的半数有效量（ED50）没有显著影响。二正丙基乙酸（800毫克/千克）可使印防己毒素惊厥的ED50显著升高，它抑制γ-氨基丁酸转氨酶活性6%，并使脑γ-氨基丁酸浓度升高26%。
