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一种求解结合平衡“n×m”情况的简单算法。

A simple algorithm for the solution of the 'n X m' case of a binding equilibrium.

作者信息

Colás A E

出版信息

Experientia. 1976 Nov 15;32(11):1487-8. doi: 10.1007/BF01937452.

DOI:10.1007/BF01937452
PMID:992009
Abstract

Accurate estimates of the equilibrium concentrations in the non-interactive reaction of several ligands with several classes of binding sites with univalent stoichiometry can be rapidly obtained by a simple method of successive approximations on a programmable desk calculator.

摘要

通过在可编程台式计算器上进行简单的逐次逼近法，能够快速获得几种配体与几类具有单价化学计量关系的结合位点发生非相互作用反应时平衡浓度的准确估计值。

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本文引用的文献

1
Analysis of protein ligand equilibria.
J Theor Biol. 1971 Jul;32(1):59-74. doi: 10.1016/0022-5193(71)90135-4.
2
Simulation of the thyroid hormone-binding protein interactions in human plasma.
J Clin Endocrinol Metab. 1970 Jun;30(6):733-51. doi: 10.1210/jcem-30-6-733.
3
A computer program for the calculation of the free ligand concentrations in cases of multiple binding to proteins.一种用于计算在与蛋白质多重结合情况下游离配体浓度的计算机程序。
Experientia. 1974 Feb 15;30(2):168-70. doi: 10.1007/BF01927713.
4
A computer program for the analysis of binding experiments.一个用于分析结合实验的计算机程序。
Comput Programs Biomed. 1973 Jul;3(2):63-78. doi: 10.1016/0010-468x(73)90022-6.
5
Computer analysis of drug-protein binding data.药物-蛋白质结合数据的计算机分析。
Ann N Y Acad Sci. 1973 Nov 26;226:69-81. doi: 10.1111/j.1749-6632.1973.tb20469.x.
6
A filter assay for steroid hormone receptors.一种用于类固醇激素受体的滤膜检测法。
Biochemistry. 1973 Jun 19;12(13):2412-6. doi: 10.1021/bi00737a007.
7
An unbiased method for estimating binding parameters in a non-cooperative binding process.
Biochim Biophys Acta. 1974 Dec 18;371(2):482-90. doi: 10.1016/0005-2795(74)90044-0.
8
Mathematical theory of cross-reactive radioimmunoassay and ligand-binding systems of equilibrium.交叉反应放射免疫分析及平衡配体结合系统的数学理论
Anal Biochem. 1972 Feb;45(2):530-56. doi: 10.1016/0003-2697(72)90216-3.
9
Binding interactions of progesterone and other C21 steroids with rat uterine cytosol.
Gynecol Invest. 1975;6(5):272-84. doi: 10.1159/000301523.