Ghate J V, Jorizzo J L
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
J Am Acad Dermatol. 1999 Jan;40(1):1-18; quiz 19-20. doi: 10.1016/s0190-9622(99)70523-2.
Behçet's disease is a complex multisystem disease diagnosed by means of clinical criteria. Clinical features include oral and genital aphthae, pustular vasculitic cutaneous lesions, and ocular, gastrointestinal, and vascular manifestations. We believe that complex aphthosis, characterized by oral or oral and genital ulcers, may be a forme fruste of Behçet's disease. Although the pathogenesis of both Behçet's disease and complex aphthosis remain unknown, immune factors, infectious agents, and effector mechanisms are implicated. Treatment is based on the severity of systemic involvement and includes topical therapies as well as colchicine, dapsone, thalidomide, and immunosuppressive agents.
白塞病是一种通过临床标准诊断的复杂多系统疾病。临床特征包括口腔和生殖器溃疡、脓疱性血管炎性皮肤病变以及眼部、胃肠道和血管表现。我们认为，以口腔或口腔及生殖器溃疡为特征的复杂性口疮可能是白塞病的一种顿挫型。尽管白塞病和复杂性口疮的发病机制尚不清楚，但免疫因素、感染因子和效应机制与之相关。治疗基于全身受累的严重程度，包括局部治疗以及秋水仙碱、氨苯砜、沙利度胺和免疫抑制剂。
