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新辅助放化疗后对潜在可切除的胰腺外分泌腺癌行胰腺切除术

[Pancreatectomy after neoadjuvant chemoradiotherapy for potentially resectable exocrine adenocarcinoma of the pancreas].

作者信息

Partensky C, Maddern G

机构信息

Fédération des spécialitiés digestives, hôpital Edouard-Herriot, Lyon, France.

出版信息

Cancer Radiother. 1998 Dec;2(6):771-4. doi: 10.1016/s1278-3218(99)80021-3.

Abstract

The last of the therapeutic modalities proposed for exocrine adenocarcinoma of the pancreas which appears to be potentially resectable, neoadjuvant chemoradiotherapy has many prerequisites: validation of the diagnosis, determination of resectability with a high degree of confidence and palliation of biliary obstruction when present. This rather complex strategy does not seem to have major deleterious effects on the operative procedure or the postoperative course. Only multicentric protocols will, in the near future, give an answer to the question of secondary toxic effects and improvement of survival of this new therapeutic strategy.

摘要

对于似乎有可能切除的胰腺外分泌腺癌,新辅助放化疗是最后提出的治疗方式之一,它有许多前提条件:诊断的确认、高度确信可切除性的判定以及存在胆道梗阻时的缓解。这种相当复杂的策略似乎对手术过程或术后病程没有重大有害影响。只有多中心方案在不久的将来才能回答这种新治疗策略的继发毒性作用问题以及生存率改善问题。

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