Dericks-Tan J S, Baumann R
Geburtshilfe Frauenheilkd. 1976 Oct;36(10):845-51.
The levels of human chorionic gonadotropin (HCG), human placental lactogen (human choriosomatomamotropin HCS) and prolactin (PRL) were determined in the serum of 72 maternity patients and the serum of the newborn infants. The determinations were done with radioimmunologic tests (RIA). These three protein hormones were also determined in the amniotic fluid and in the maternal serum from 4-6 days prior to the delivery of the infant. The concentration of HCG or HCS in the serum of the newborn infants was a mean 0.43 or 0.37% of the level in the maternal serum. The concentration of PRL in the serum of the newborn was 118% and slightly higher than in the serum of the mothers. The concentration in the amniotic fluid was 1.5% for HCG, 5.8% for HCS, and 252% for PRL, compared to the corresponding levels in the maternal serum. The fact that the hormone concentrations in the amniotic fluid are significantly higher than in the serum of the newborn suggests excretion of the hormones from the fetal circulation via the fetal liver and the fetal kidney. The high levels of PRL in the maternal and the newborn serum may be caused by the high concentrations of estrogen or progesterone. Increased during the course of the pregnancy there was a significant sex linked difference in the level of HCG in the maternal serum correlated to the sex of the newborn infant.
测定了72例产妇血清及新生儿血清中人绒毛膜促性腺激素（HCG）、人胎盘催乳素（人绒毛膜生长催乳素HCS）和催乳素（PRL）的水平。采用放射免疫分析法（RIA）进行测定。在羊水及婴儿分娩前4 - 6天的母血中也测定了这三种蛋白质激素。新生儿血清中HCG或HCS的浓度平均为母血中水平的0.43%或0.37%。新生儿血清中PRL的浓度为母血的118%，略高于母亲血清中的浓度。与母血中相应水平相比，羊水中HCG的浓度为1.5%，HCS为5.8%，PRL为252%。羊水激素浓度显著高于新生儿血清这一事实表明，激素是从胎儿循环经胎儿肝脏和胎儿肾脏排泄的。母血和新生儿血清中PRL水平较高可能是由高浓度的雌激素或孕酮引起的。在孕期过程中，母血中HCG水平存在与新生儿性别相关的显著性别差异。
