Mege R M, Padilla F, Lambert M, Nicolet M
INSERM U 440, Institut du Fer à Moulin, Paris, France.
Pathol Biol (Paris). 1998 Dec;46(10):796-801.
Various cell adhesion molecules of the cadherin family characterize the neuromuscular system. During development, cadherins N and M are sequentially expressed by myogenic cells during the two waves of myoblast fusion. Two other cadherins, called 6 and 11, are also expressed during the embryonic musculature development. In adult muscle, cadherins N and M, whose expression is suppressed by muscle activity, persist only at the neuromuscular junction and are reexpressed at the surface of denervated fibers. Cadherins N, M and E are also expressed in adult peripheral nerves. Their differential localization at Schmidt-Lanterman clefts, Ranvier nodes and neuromuscular junctions suggest that these molecules contribute to the stabilization of specialized intercellular contacts. In conclusion, a combination of cadherins, the expression of which is spatially and temporally regulated, participates in the differentiation and maintenance of the organization of the various cellular and tissular components of the neuromuscular system.
钙黏蛋白家族的多种细胞黏附分子是神经肌肉系统的特征。在发育过程中，成肌细胞在成肌细胞融合的两波过程中依次表达N型和M型钙黏蛋白。另外两种钙黏蛋白，即6型和11型，也在胚胎肌肉组织发育过程中表达。在成年肌肉中，N型和M型钙黏蛋白的表达受肌肉活动抑制，仅在神经肌肉接头处持续存在，并在失神经支配纤维的表面重新表达。N型、M型和E型钙黏蛋白也在成年外周神经中表达。它们在施密特-兰特尔曼切迹、郎飞结和神经肌肉接头处的差异定位表明，这些分子有助于稳定特殊的细胞间接触。总之，多种钙黏蛋白的组合，其表达在空间和时间上受到调控，参与了神经肌肉系统各种细胞和组织成分的分化和组织结构的维持。
