吉法酯可增加兔结膜中PAS阳性细胞密度。
Gefarnate increases PAS positive cell density in rabbit conjunctiva.
作者信息
Nakamura M, Endo K, Nakata K, Hamano T
机构信息
Nara Research and Development Center, Santen Pharmaceutical Co, Ltd, Japan.
出版信息
Br J Ophthalmol. 1998 Nov;82(11):1320-3. doi: 10.1136/bjo.82.11.1320.
AIMS
The effects of three drugs for the treatment of gastritis and gastric ulcer--gefarnate, ecabet sodium, and troxipide--on periodic acid Schiff (PAS) positive cell density in rabbit conjunctiva in vivo were investigated.
METHODS
Eye drops containing gefarnate (0.1%, 1%), ecabet sodium (0.1%, 1%), or troxipide (0.1%, 1%) were instilled in both eyes of rabbits, six times a day for 7 days. On the eighth day, filter paper was gently pressed on the bulbar and palpebral conjunctiva, and impression cytology was performed with PAS staining. Three points in each specimen were selected randomly, and PAS stained cells were counted.
RESULTS
The instillation of gefarnate increased PAS positive cell density significantly at the concentration of 1% (p < 0.05). In contrast, instillation of ecabet sodium or troxipide failed to change PAS positive cell density.
CONCLUSIONS
These results demonstrated that gefarnate stimulates PAS positive cell density in rabbit conjunctiva.
目的
研究三种治疗胃炎和胃溃疡的药物——吉法酯、依卡倍特钠和曲昔派特——对家兔结膜中高碘酸希夫（PAS）阳性细胞密度的体内影响。
方法
将含有吉法酯（0.1%、1%）、依卡倍特钠（0.1%、1%）或曲昔派特（0.1%、1%）的滴眼液滴入家兔双眼，每天6次，共7天。第8天，用滤纸轻轻按压球结膜和睑结膜，并进行PAS染色的印迹细胞学检查。在每个标本中随机选择三个点，对PAS染色的细胞进行计数。
结果
吉法酯在浓度为1%时显著增加了PAS阳性细胞密度（p < 0.05）。相比之下，滴入依卡倍特钠或曲昔派特未能改变PAS阳性细胞密度。
结论
这些结果表明吉法酯可刺激家兔结膜中PAS阳性细胞密度。
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