Potent 3-spiropiperidine growth hormone secretagogues.
作者信息
Yang L, Morriello G, Prendergast K, Cheng K, Jacks T, Chan W W, Schleim K D, Smith R G, Patchett A A
机构信息
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 1998 Jan 6;8(1):107-12. doi: 10.1016/s0960-894x(97)10199-8.
PMID:9925440
Abstract
Systematic SAR studies of the different regioisomers and homologues of the spiro(indane-1,4-piperidine) moiety in the growth hormone secretagogue L-162,752 are presented. Among them, spiro(3H-1-benzopyran-2,3-piperidine) was found to afford secretagogues with low nanomolar in vitro activity.
摘要
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