[(A1-β-丙氨酸)胰岛素]
[(A1-beta-Alanine) insulin].
作者信息
Geiger R, Geisen K, Regitz G, Summ H D
出版信息
Hoppe Seylers Z Physiol Chem. 1976 Sep;357(9):1267-70. doi: 10.1515/bchm2.1976.357.2.1267.
PMID:992580
Abstract
Starting from porcine insulin, A1-glycine was substituted by beta-alanine. The blood sugar lowering effect of the new analogue in the rabbit is about 45% of that of insulin. The half-maximal binding to partially purified rat liver receptors is about 46%, to transformed human lymphocytes about 54%, compared to insulin.
摘要
从猪胰岛素开始，将A1位的甘氨酸替换为β-丙氨酸。新类似物在兔体内的降血糖作用约为胰岛素的45%。与胰岛素相比，其与部分纯化的大鼠肝脏受体的半数最大结合率约为46%，与转化的人淋巴细胞的半数最大结合率约为54%。
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