Moore M A, Kunimoto T, Park C B, Takasuka N, Tsuda H
Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo, Japan.
Eur J Cancer Prev. 1998 Dec;7(6):473-8. doi: 10.1097/00008469-199812000-00008.
Relative incidence rates of lung cancers demonstrate marked international variation in values for the different histological sub-types. In order to determine whether adenocarcinomas (ACs) in this site might share risk factors with other ACs, for example, in the breast, prostate, oesophagus and colon, a comparison of data in the IARC/WHO Cancer Incidence in Five Continents (Volume VII) was made for selected registries in Europe. Significant correlations were found between lung AC incidences/100,000 population and prostate and colon cancers in males (P < 0.005 and P < 0.05, respectively) and for breast and colon in females (P < 0.05 for both). Partial correlation coefficients were significant for lung and colon (P < 0.001) and prostate and colon (P < 0.005) in men, and for breast and colon in women (P < 0.005). A significant negative correlation with prostate cancer was noted for lung ACs in men. The results provide support for shared risk factors between lung Acs and colon cancers but do not indicate any link with AC development in the oesophagus. Data from registries in the UK and Italy were remarkable for high incidences of oesophageal and lung ACs, respectively, pointing to major differences in environmental risk factor or beneficial influence acting on these sites between the two countries.
肺癌的相对发病率在不同组织学亚型的数值上呈现出显著的国际差异。为了确定该部位的腺癌（AC）是否可能与其他部位的腺癌（如乳腺、前列腺、食管和结肠）有共同的风险因素，对欧洲选定登记处的国际癌症研究机构/世界卫生组织《五大洲癌症发病率》（第七卷）中的数据进行了比较。发现男性中肺腺癌发病率/10万人口与前列腺癌和结肠癌之间存在显著相关性（分别为P < 0.005和P < 0.05），女性中乳腺癌和结肠癌之间也存在显著相关性（两者均为P < 0.05）。男性中肺与结肠（P < 0.001）、前列腺与结肠（P < 0.005）以及女性中乳腺与结肠的偏相关系数均显著（P < 0.005）。男性肺腺癌与前列腺癌呈显著负相关。结果支持肺腺癌和结肠癌之间存在共同风险因素，但未表明与食管腺癌的发生有任何关联。英国和意大利登记处的数据分别显示食管腺癌和肺腺癌的高发病率，这表明两国在影响这些部位的环境风险因素或有益影响方面存在重大差异。
