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打鼾、阻塞性睡眠呼吸暂停与手术

Snoring, obstructive sleep apnea, and surgery.

作者信息

Barthel S W, Strome M

机构信息

Department of Otolaryngology and Communicative Disorders, Cleveland Clinic Foundation, Ohio, USA.

出版信息

Med Clin North Am. 1999 Jan;83(1):85-96. doi: 10.1016/s0025-7125(05)70089-4.

Abstract

Snoring and OSA syndrome are prevalent and important causes of sleep disturbance. Snoring, historically considered to be only a habitual annoyance, has significant physical and social consequences. OSA is now considered to be a major public health concern with significant morbidity and mortality. CPAP is considered the treatment of choice for OSA syndrome, but poor patient acceptance and compliance remain problematic. Surgical procedures have been developed to alter the offending anatomic abnormalities responsible for OSA. Identification of the offending anatomic site with application of the most appropriate surgical procedure is essential for effective surgical treatment of OSA. When the region of the retropalate is correctly identified as the site of obstruction, UPPP can effectively treat OSA in a majority of patients. Surgical correction of nasal obstruction is advocated in conjunction with sleep apnea surgery when nasal obstruction exists. In OSA patients with retrolingual airway obstruction, a number of surgical procedures have been performed, with or without UPPP, with some improvement over UPPP alone. MMO has been effective in the treatment of OSA in patients with significant retrolingual airway obstruction with contributing skeletal abnormalities and in patients who have failed multiple other surgical procedures. MMO, however, is a procedure of considerable magnitude, requiring extensive oromaxillofacial surgical expertise. MMO is likely appropriate only in a limited number of patients. Tracheostomy is completely effective in the treatment of OSA syndrome but is undesirable to patients and is associated with significant physical and emotional morbidity. Nonetheless, tracheostomy can be lifesaving and remains an option for patients with severe OSA with serious associated cardiovascular complications, who cannot tolerate CPAP, and for whom other interventions are ineffective or unacceptable. Effective surgical treatment of snoring has been accomplished with UPPP and LAUP. LAUP is less invasive, less morbid, more cost-effective, and better tolerated and is likely the most appropriate procedure for debilitating symptomatic snoring. Currently, LAUP is not recommended for the treatment of OSA, despite some efficacy in patients with mild OSA. Exclusion of OSA in patients undergoing LAUP for snoring is important.

摘要

打鼾和阻塞性睡眠呼吸暂停综合征(OSA)是睡眠障碍的常见且重要原因。打鼾,历史上仅被视为一种习惯性烦恼,却会产生重大的身体和社会后果。如今,OSA被认为是一个重大的公共卫生问题,具有显著的发病率和死亡率。持续气道正压通气(CPAP)被视为OSA综合征的首选治疗方法,但患者接受度和依从性较差仍是问题。已经开发出手术程序来改变导致OSA的相关解剖异常。识别出导致问题的解剖部位并应用最合适的手术程序对于OSA的有效手术治疗至关重要。当软腭后区域被正确识别为阻塞部位时,悬雍垂腭咽成形术(UPPP)可有效治疗大多数患者的OSA。当存在鼻阻塞时,主张在睡眠呼吸暂停手术的同时进行鼻阻塞的手术矫正。对于舌后气道阻塞的OSA患者,已进行了多种手术程序,无论是否联合UPPP,相比单纯UPPP都有一定改善。下颌骨前移术(MMO)对于存在显著舌后气道阻塞且伴有骨骼异常的患者以及多次其他手术失败的患者,在治疗OSA方面已取得成效。然而,MMO是一个规模较大的手术,需要广泛的口腔颌面外科专业知识。MMO可能仅适用于少数患者。气管切开术在治疗OSA综合征方面完全有效,但患者不愿接受,且伴有显著的身体和情感方面的发病风险。尽管如此,气管切开术可挽救生命,对于患有严重OSA且伴有严重相关心血管并发症、无法耐受CPAP且其他干预措施无效或不可接受的患者仍是一种选择。UPPP和激光辅助悬雍垂腭成形术(LAUP)已成功实现对打鼾的有效手术治疗。LAUP创伤较小、发病率较低、更具成本效益且耐受性更好,可能是治疗症状性打鼾的最合适手术。目前,尽管LAUP对轻度OSA患者有一定疗效,但不推荐用于治疗OSA。在因打鼾接受LAUP的患者中排除OSA很重要。

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