Fuxe K, Jansson A, Diaz-Cabiale Z, Andersson A, Tinner B, Finnman U B, Misane I, Razani H, Wang F H, Agnati L F, Ogren S O
Department of Neuroscience, Karolinska Institute, Stockholm, Sweden.
Ann N Y Acad Sci. 1998 Dec 21;863:274-90. doi: 10.1111/j.1749-6632.1998.tb10702.x.
The reciprocal interactions between galanin and 5-HT1A receptors in the rat brain are presented. Galanin and its NH2-terminal fragments antagonize 5-HT1A receptor-mediated transmission at the postjunctional level, whereas galanin receptor activation mimics the inhibitory action of 5-HT1A receptor activation at the soma-dendritic level, leading to reductions of 5-HT metabolism and release. These interactions have been shown in both receptor binding studies and functional studies. In view of the present findings, galanin antagonists may represent a new type of anti-depressant drug, based on the 5-HT hypothesis of depression, by enhancing 5-HT release and postjunctional 5-HT1A-mediated transmission. Moreover, following intracerebroventricular injection galanin was found to be internalized in a population of hippocampal nerve cells mainly representing GABA, somatostatin, and/or NPY-immunoreactive nerve cells. The relevance of these findings is discussed in relation to the concept of volume transmission.
本文介绍了大鼠脑中甘丙肽与5-HT1A受体之间的相互作用。甘丙肽及其NH2末端片段在突触后水平拮抗5-HT1A受体介导的传递，而甘丙肽受体激活在胞体-树突水平模拟5-HT1A受体激活的抑制作用，导致5-羟色胺（5-HT）代谢和释放减少。这些相互作用在受体结合研究和功能研究中均已得到证实。基于目前的研究结果，考虑到抑郁症的5-HT假说，甘丙肽拮抗剂可能通过增强5-HT释放和突触后5-HT1A介导的传递，代表一种新型的抗抑郁药物。此外，脑室内注射后发现甘丙肽在一群主要代表γ-氨基丁酸（GABA）、生长抑素和/或神经肽Y（NPY）免疫反应性神经细胞的海马神经细胞中被内化。本文结合容积传递的概念讨论了这些发现的相关性。
