Zargar A H, Laway B A, Masoodi S R, Wani A I, Salahuddin M
Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Kashmir, India.
J Paediatr Child Health. 1998 Dec;34(6):571-6. doi: 10.1046/j.1440-1754.1998.00308.x.
To determine the aetiological causes of short stature in a developing region of the world.
A retrospective analysis was made of data from 193 subjects who were primarily evaluated for short stature in the Endocrinology Department, Institute of Medical Sciences, Kashmir, India. These subjects had a height of more than 3 standard deviations (SD) below the mean for their age and sex, and were seen over a decade (January 1987 to December 1996). A logical and comprehensive clinical and investigative protocol was followed to identify the aetiology of short stature.
Growth hormone deficiency was the commonest identifiable cause of short stature and accounted for 22.8% of cases. Thirty-six subjects (18.7%) had a normal variant short stature. Renal tubular acidosis was diagnosed in 10.4%, primary hypothyroidism, malnutrition and hypothalamic syndrome in 7.8% each, and growth hormone insensitivity syndrome in 4.1% cases.
We conclude that, in addition to growth hormone deficiency and normal variant short stature, distal renal tubular acidosis and growth hormone insensitivity syndrome are significant causes of short stature in India.
确定世界某发展中地区身材矮小的病因。
对印度克什米尔医学科学研究所内分泌科主要因身材矮小接受评估的193名受试者的数据进行回顾性分析。这些受试者的身高比其年龄和性别的均值低3个以上标准差，且观察时间超过十年（1987年1月至1996年12月）。遵循逻辑且全面的临床和调查方案来确定身材矮小的病因。
生长激素缺乏是身材矮小最常见的可识别病因，占病例的22.8%。36名受试者（18.7%）有正常变异型身材矮小。诊断为肾小管酸中毒的占10.4%，原发性甲状腺功能减退、营养不良和下丘脑综合征各占7.8%，生长激素不敏感综合征占4.1%。
我们得出结论，除生长激素缺乏和正常变异型身材矮小外，远端肾小管酸中毒和生长激素不敏感综合征是印度身材矮小的重要病因。
