环境中的1-甲基-4-苯基-1,2,3,6-四氢吡啶是帕金森病病因的一个因素？
Environmental MPTP as a factor in the aetiology of Parkinson's disease?
作者信息
Goodwin B L, Kite G C
机构信息
Department of Pharmacy, King's College London, United Kingdom.
出版信息
J Neural Transm (Vienna). 1998;105(10-12):1265-9. doi: 10.1007/s007020050129.
The possibility that parkinsonism might be caused by environmental MPTP present in soot formed from partial combustion of coal has been assessed. Soot was fractionated and the bases were examined by gas chromatography-mass spectrometry (GC-MS) for 1,2,3,6-tetrahydro-1-methyl-4-phenylpyridine (MPTP). Although this method was considered to be capable of detecting MPTP in soot at about 1 in 10(-6) its presence was not detected.
已经评估了帕金森氏症可能由煤不完全燃烧形成的煤烟中存在的环境性1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）引起的可能性。对煤烟进行了分级分离，并通过气相色谱-质谱联用仪（GC-MS）检测其中的碱类物质是否含有1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）。尽管该方法被认为能够检测到煤烟中约百万分之一含量的MPTP，但未检测到其存在。
Zotero 插件