Lewi P J
Int Pharmacopsychiatry. 1976;11(3):181-9. doi: 10.1159/000468229.
The clinical and pharmacological activity spectra of the neuroleptics can be projected into a map where compounds with similar spectra, but with possibly different potencies, are grouped together. The spectral maps were devised for classification and for the prediction of therapeutic effects from pharmacological observations. Significant correlations are observed within and between pharmacological and clinical classifications (Spearman test, p less than 0.01). Pharmacological maps appear to be one-dimensional and resemble the Lambert incisive/sedative bipolar scale. The Liége clinical physiognomy of neuroleptics shows an additional component which may be related to antimanic/antiaustistic effects.
抗精神病药物的临床和药理活性谱可以投射到一张图谱中，具有相似谱但可能效力不同的化合物被归为一组。这些谱图是为分类以及根据药理学观察预测治疗效果而设计的。在药理学分类和临床分类内部及之间观察到显著相关性（斯皮尔曼检验，p小于0.01）。药理图谱似乎是一维的，类似于兰伯特兴奋/镇静双极量表。列日抗精神病药物的临床面相学显示出一个额外的成分，可能与抗躁狂/抗自闭症作用有关。
