Morozov I S, Kleĭmenova N N
Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Eksp Klin Farmakol. 1998 Nov-Dec;61(6):51-3.
The positive effect of bromantan (0.5-50 mg/kg) on the efficiency of physical work of mice and rats (swimming test, running on a treadmill) exceeds that of phenamine administered in optimal doses by 1.3-1.6 times. Such an effect of bromantan lasts no less than 24 h. The drug delays decrease of physical efficiency and restores it sooner in repeated extreme running loads, prevents in rats the corresponding electron-microscopic changes in the cardiomyocyte and myocyte mitochondria of the skeletal muscles. The data obtained suggest that the positive effect of bromantan on the physical efficiency is associated not only with its psychostimulating action but also with the membrane-protecting effect.
溴antan（0.5 - 50毫克/千克）对小鼠和大鼠体力活动效率（游泳试验、跑步机跑步）的积极作用比以最佳剂量给药的苯丙胺高出1.3 - 1.6倍。溴antan的这种作用持续不少于24小时。该药物可延缓体力效率的下降，并在重复的极限跑步负荷中更快地恢复体力，可防止大鼠骨骼肌心肌细胞和肌细胞线粒体出现相应的电子显微镜下的变化。所获得的数据表明，溴antan对体力效率的积极作用不仅与其精神刺激作用有关，还与其膜保护作用有关。
