Fedotova Iu O
Institute for Experimental Medicine, Russian Academy of Medical Sciences, St.-Petersburg.
Zh Vyssh Nerv Deiat Im I P Pavlova. 1998 Nov-Dec;48(6):980-8.
The present study was designed to explore the comparative influence of thyroid, adrenal, and gonadal hormones on the capability for learning, retention of memory traces and behavior in male rats under conditions of systemic administration of synthetic hormonal preparations. Behavior of animals was assessed during the active and passive avoidance learning, as well as in the open-field test. It was established that the increase in the level of corticosteroid, thyroid, or gonadal hormones did not affect the formation and retention of passive avoidance learning. Excess of corticosteroids increased behavioral activity but impaired the active avoidance learning and the following reproduction of the acquired reaction. Excess of gonadal hormones dramatically impaired the performance in the conditioned active avoidance test, and excess of thyroid hormones improved the active avoidance learning.
本研究旨在探讨在全身给予合成激素制剂的条件下,甲状腺激素、肾上腺激素和性腺激素对雄性大鼠学习能力、记忆痕迹保留及行为的比较影响。在主动和被动回避学习过程以及旷场试验中评估动物的行为。结果表明,皮质类固醇激素、甲状腺激素或性腺激素水平的升高并不影响被动回避学习的形成和保留。皮质类固醇激素过量会增加行为活动,但会损害主动回避学习及随后习得反应的再现。性腺激素过量会显著损害条件性主动回避试验中的表现,而甲状腺激素过量则会改善主动回避学习。