2型单纯疱疹病毒感染诱导HEp-2细胞凋亡
Induction of apoptosis in HEp-2 cells by infection with herpes simplex virus type 2.
作者信息
Koyama A H, Akari H, Adachi A, Goshima F, Nishiyama Y
机构信息
Department of Virology, School of Medicine, University of Tokushima, Japan.
出版信息
Arch Virol. 1998;143(12):2435-41. doi: 10.1007/s007050050473.
PMID:9930199
Abstract
Although herpes simplex virus type 1 (HSV-1) does not induce apoptosis in infected HEp-2 cells, herpes simplex virus type 2 (HSV-2) did induce apoptosis in a small but significant fraction of the same cells. Apoptosis was not observed in Vero or HeLa cells infected with HSV-2. In addition, HSV-2 infection in the presence of cycloheximide induced extensive apoptosis of HEp-2 or HeLa cells.
摘要
虽然1型单纯疱疹病毒（HSV-1）不会在感染的HEp-2细胞中诱导细胞凋亡，但2型单纯疱疹病毒（HSV-2）确实会在同一细胞的一小部分但数量可观的细胞中诱导细胞凋亡。在感染HSV-2的Vero或HeLa细胞中未观察到细胞凋亡。此外，在存在环己酰亚胺的情况下，HSV-2感染会诱导HEp-2或HeLa细胞广泛凋亡。
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