生命最初3年的反复呼吸道感染及学龄期的特应性反应。

Recurrent respiratory tract infections during the first 3 years of life and atopy at school age.

作者信息

Nystad W, Skrondal A, Njå F, Hetlevik O, Carlsen K H, Magnus P

机构信息

Department of Population Health Sciences, National Institute of Public Health, Oslo, Norway.

出版信息

Allergy. 1998 Dec;53(12):1189-94. doi: 10.1111/j.1398-9995.1998.tb03840.x.

DOI:10.1111/j.1398-9995.1998.tb03840.x

PMID:9930596

Abstract

BACKGROUND

The hypothesis that infections reduce the risk of atopy was investigated by estimating the association between recurrent respiratory tract infections during the first 3 years of life and atopy at school age.

METHODS

According to surveys in three different areas of Norway, children were classified into three groups: asthma, wheeze without asthma (wheeze), and no asthma/no wheeze. The skin prick test (SPT) was conducted on a stratified random sample of children (n = 502). The outcome was at least one positive SPT. The exposure variable was retrospective parental report of respiratory tract infections during the first 3 years of life.

RESULTS

Infections were negatively associated with atopy, crude odds ratio (cOR) = 0.3, 95% confidence interval (95% CI) 0.1-0.7, in the asthma group. A similar association was present in children with wheeze cOR = 0.4 (95% CI 0.1-1.2). The number of siblings was not associated with atopy in any group. Infections remained negatively associated with atopy in children with asthma, aOR = 0.3 (95% CI 0.1-0.7), in a logistic regression model adjusting for confounding factors. A similar pattern was present in the wheeze group.

CONCLUSIONS

Recurrent respiratory tract infections during the first 3 years of life are negatively associated with atopy at school age in children with asthma.

摘要

背景

通过评估生命最初3年反复呼吸道感染与学龄期特应性疾病之间的关联，对感染降低特应性疾病风险这一假说进行了研究。

方法

根据挪威三个不同地区的调查，将儿童分为三组：哮喘组、无哮喘的喘息组（喘息组）和无哮喘/无喘息组。对分层随机抽取的儿童样本（n = 502）进行皮肤点刺试验（SPT）。观察结果为至少一次SPT呈阳性。暴露变量为回顾性家长报告的儿童生命最初3年的呼吸道感染情况。

结果

在哮喘组中，感染与特应性疾病呈负相关，粗比值比（cOR）= 0.3，95%置信区间（95%CI）为0.1 - 0.7。喘息组儿童中也存在类似关联，cOR = 0.4（95%CI 0.1 - 1.2）。在任何组中，兄弟姐妹数量与特应性疾病均无关联。在调整混杂因素的逻辑回归模型中，哮喘儿童中感染与特应性疾病仍呈负相关，校正后比值比（aOR）= 0.3（95%CI 0.1 - 0.7）。喘息组中也呈现类似模式。