Lorenz-Meyer H, Köhn R, Riecken E O
Histochemistry. 1976 Oct 22;49(2):123-9. doi: 10.1007/BF00495676.
In contrast to the human small intestine with predominantly fingerlike villi, trapezoid forms are encountered in the small bowel of the rat. For this reason, it is doubtful whether it is sufficient to measure the villus height alone as a representative parameter for the assessment of the villus surface. In this study, the method developed by Clarke is employed to calculate the villus surface per unit area of intestine. The data obtained by this method are compared with those estimated planimetrically. Correlations were then established between the absorptive capacity and enzymatic activity of the intestinal mucosa on the one hand, and the villus height or the villus area obtained by each method on the other hand. Under our experimental conditions--a hyperregenerative transformation of the intestinal mucosa caused by chronic exposure to glucagon--the results indicate that the calculated villus surface per unit area of small intestine correlates better than the villus height with the functional parameters of the intestinal mucosa.
与主要具有指状绒毛的人类小肠不同，在大鼠小肠中可发现梯形形态。因此，仅测量绒毛高度作为评估绒毛表面的代表性参数是否足够值得怀疑。在本研究中，采用克拉克开发的方法来计算每单位肠面积的绒毛表面。将通过该方法获得的数据与通过平面测量法估计的数据进行比较。然后在一方面肠道黏膜的吸收能力和酶活性与另一方面通过每种方法获得的绒毛高度或绒毛面积之间建立相关性。在我们的实验条件下——慢性暴露于胰高血糖素导致肠道黏膜的过度再生转变——结果表明，每单位小肠面积计算出的绒毛表面与肠道黏膜的功能参数的相关性比绒毛高度更好。
