Roethy W, Yamamoto N, Burkhoff D
Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
Semin Thorac Cardiovasc Surg. 1999 Jan;11(1):24-8. doi: 10.1016/s1043-0679(99)70015-8.
Within the past few years, transmyocardial laser revascularization (TMR) has attracted the attention of cardiologists and cardiac surgeons as a therapy for patients suffering from otherwise treatable coronary artery disease. Clinical studies have consistently shown symptomatic improvement that lasts at least 1 year in a majority of patients. The original hypothesis that prompted development of the technique was that direct myocardial perfusion from the chamber could be achieved through chronically patent channels, as is the case in reptilian hearts. Results of our early studies failed to support this hypothesis and we turned to investigations aimed at testing other possible explanations. The experiments, which are reviewed in this article, showed that TMR enhances vascular growth in ischemic myocardium.
在过去几年中，经心肌激光血运重建术（TMR）作为治疗患有其他可治疗的冠状动脉疾病患者的一种疗法，已引起心脏病学家和心脏外科医生的关注。临床研究一直表明，大多数患者的症状改善可持续至少1年。促使该技术发展的最初假设是，如同爬行动物心脏那样，可通过长期开放的通道实现从心腔直接向心肌灌注。我们早期研究的结果未能支持这一假设，于是我们转向旨在检验其他可能解释的研究。本文所综述的实验表明，TMR可促进缺血心肌中的血管生长。
