7-（2-氨基甲基苯乙酰氨基）-3-（1-羧甲基四氮唑-5-基硫甲基）-3-头孢烯-4-羧酸
7-(2-aminomethylphenylacetamido)-3-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.
作者信息
Gottstein W J, Kaplan M A, Cooper J A, Silver V H, Nachfolger S J, Granatek A P
出版信息
J Antibiot (Tokyo). 1976 Nov;29(11):1226-9. doi: 10.7164/antibiotics.29.1226.
PMID:993108
Abstract
The synthesis of 7-(2-aminomethylphenylacetamido)-(1-carboxymethyltetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid (BL-S786) is described and the antimicrobial activities are compared with cefazolin and cefamandole. The compound exhibits broad antimicrobial spectrum, produces high intramuscular blood levels in mice and demonstrates a high degree of therapeutic efficacy in experimental bacterial infections in rodents.
摘要
描述了7-(2-氨基甲基苯乙酰胺基)-(1-羧甲基四氮唑-5-基硫甲基)-3-头孢烯-4-羧酸（BL-S786）的合成，并将其抗菌活性与头孢唑林和头孢孟多进行了比较。该化合物具有广谱抗菌活性，在小鼠体内肌内注射后血药浓度较高，并且在啮齿动物的实验性细菌感染中显示出高度的治疗效果。
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