[其他喜树碱类药物：除伊立替康和拓扑替康之外的喜树碱类似物的最新进展]
[The other camptothecins: recent advances with camptothecin analogues other than irinotecan and topotecan].
作者信息
Lavergne O, Bigg D C
机构信息
Institut Henri-Beaufour, Les Ulis, France.
出版信息
Bull Cancer. 1998 Dec;Spec No:51-8.
PMID:9932086
Abstract
The first part of this review summarizes the clinical developments concerning camptothecin, 9-aminocamptothecin, 9-nitrocamptothecin, GG-211 and DX-8951f. The second part covers the recent developments of research on CPT analogs: CPTs with solubilizing substituents, CPTs with activating substituents, CPTs with dual activity, CPT prodrugs and CPTs with stabilized lactones.
摘要
本综述的第一部分总结了关于喜树碱、9-氨基喜树碱、9-硝基喜树碱、GG-211和DX-8951f的临床进展。第二部分涵盖了喜树碱类似物的最新研究进展：具有增溶取代基的喜树碱、具有活化取代基的喜树碱、具有双重活性的喜树碱、喜树碱前药以及内酯稳定的喜树碱。
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