衰老草履虫内吞能力的丧失。细胞质细胞器的重要性。
Loss of endocytic capacity in aging Paramecium. The importance of cytoplasmic organelles.
作者信息
Smith-Sonneborn J, Rodermel S R
出版信息
J Cell Biol. 1976 Nov;71(2):575-88. doi: 10.1083/jcb.71.2.575.
Abstract
Aged cells have significantly fewer food vacuoles and ingest fewer bacteria than young cells. Loss of food vacuoles was explained by a decreasing difference in the food vacuole formation and excretion rates; the formation rate declined more rapidly than the excretion rate, approaching equivalence at 160 fissions, when the proportion of cells with no food vacuoles, in the presence of excess food, abruptly increased. A model for cellular aging is presented in which control of organelle numbers and cyclical interactions between the nucleus and cytoplasm may be of critical importance.
摘要
衰老细胞的食物泡明显少于年轻细胞，摄取的细菌也比年轻细胞少。食物泡的减少是由于食物泡形成和排泄速率的差异减小；形成速率的下降比排泄速率更快，在160次分裂时接近相等，此时在食物过量的情况下无食物泡的细胞比例突然增加。本文提出了一个细胞衰老模型，其中细胞器数量的控制以及细胞核与细胞质之间的周期性相互作用可能至关重要。
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