糖类抗原195与癌胚抗原用于胰腺癌诊断的比较研究

Comparative study of carbohydrate antigen 195 and carcinoembryonic antigen for the diagnosis of pancreatic carcinoma.

作者信息

Andicoechea A, Vizoso F, Alexandre E, Martínez A, Cruz Díez M, Riera L, Martinez E, Ruibal A

机构信息

Servicio de Cirugía General, Hospital de Jove, Avenida Eduardo Castro s/n, Apartado 385, 33290 Gijón, Asturias, Spain.

出版信息

World J Surg. 1999 Mar;23(3):227-31; discussion 231-2. doi: 10.1007/pl00013182.

DOI:10.1007/pl00013182

PMID:9933690

Abstract

The expression CA195 in serum, defined by monoclonal antibody CC3C195 (IgM), was studied in 67 patients with pancreatic cancer and in 138 patients with biliary or pancreatic benign disease. The results were compared with carcinoembryonic antigen (CEA) expression. The overall sensitivity of the CA195 assay (> 12 U/ml) was higher than that for CEA (89.5% vs. 53.7%) (p < 0.001). Sensitivity was increased to 92.5% with the simultaneous use of the two antigens, but the difference was statistically significant only with CEA (p < 0.001). The specificity of CA195 calculated from all patients with benign diseases was lower than that of CEA (73.1% vs. 89.8%). However, using a cutoff value of 100 U/ml for CA195, the specificity of this antigen (82%) was higher than that of CEA. These results demonstrate that marked elevations of tumor antigen CA195 are relatively specific for pancreatic carcinoma, and that this antigen is superior to CEA for diagnosing pancreatic cancer by virtue of its higher sensitivity.

摘要

采用单克隆抗体CC3C195（IgM）对67例胰腺癌患者及138例胆胰良性疾病患者血清中的CA195表达情况进行了研究，并将结果与癌胚抗原（CEA）表达情况进行比较。CA195检测（>12 U/ml）的总体敏感性高于CEA（89.5%对53.7%）（p<0.001）。两种抗原同时使用时，敏感性提高到92.5%，但仅与CEA比较差异有统计学意义（p<0.001）。根据所有良性疾病患者计算得出的CA195特异性低于CEA（73.1%对89.8%）。然而，将CA195的临界值设定为100 U/ml时，该抗原的特异性（82%）高于CEA。这些结果表明，肿瘤抗原CA195的显著升高对胰腺癌具有相对特异性，并且该抗原凭借其较高的敏感性在诊断胰腺癌方面优于CEA。