杰出科学家讲座系列。肾脏发育的新进展。

Distinguished Scientists Lecture Series. New developments in kidney development.

作者信息

Hammerman M R

机构信息

George M. O'Brien Kidney and Urological Disease Center, Renal Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

出版信息

Nephron. 1999 Feb;81(2):131-5. doi: 10.1159/000045267.

DOI:10.1159/000045267

PMID:9933746

Abstract

BACKGROUND/AIMS: The number of kidney transplantations performed per year is limited due to the availability of donor organs. One possible solution to the organ shortage is the use of renal xenografts. However, the transplantation of xenografts is complicated by rejection.

METHODS

It has been postulated that the host immune response might be attenuated following the transplantation of embryonic kidneys (metanephroi) rather than developed (adult kidneys). Transplanted metanephroi become chimeric organs in that their blood supply originates from the host. It is possible to transplant a developing metanephros, without the use of immunosuppression, from one outbred rat to another.

RESULTS

Transplanted metanephroi grow, develop, become vascularized, and function in host rats. In contrast, developed adult kidneys transplanted from one rat to another undergo rejection within 7 days after transplantation.

CONCLUSIONS

These observations suggest that metanephric tissue may be less immunogenic than adult kidney. Transplantation of metanephroi represents a new development that could lead to a novel therapeutic approach to the treatment of chronic renal failure.

摘要

背景/目的：由于供体器官的可获得性，每年进行的肾移植数量有限。器官短缺的一个可能解决方案是使用肾异种移植。然而，异种移植会因排斥反应而变得复杂。