Jarrard L E
J Comp Physiol Psychol. 1976 Nov;90(11):1035-50. doi: 10.1037/h0078659.
For a study of the structure and function of the different hippocampal cell fields, a surgical approach was devised that permitted selective damage to either the hippocampal subdivisions or the major efferent projections. Neuroanatomical techniques were used in Experiment 1 to verify the selective nature of the lesions and to provide information concerning differential hippocampal projections. In Experiment, 2, rats with selective hippocampal lesions were tested on a series of tasks chosen to measure various aspects of behavior. Animals with fimbrial lesions interrupting connections between the CA3-CA4 cell fields and the septal region were similar to animals with extensive hippocampal lesions in being more active than the other groups at night, more active during the day, and more affected by deprivation. In addition, both groups were facilitated in acquisition of a shuttle box avoidance task. Extensive damage to the hippocampus and more selective damage to the CA1 pyramidal cell field resulted in impaired spatial reversal learning. The results are interpreted as providing support for the view that the two main subdivisions of the hippocampus, the CA1 and CA3-CA4 cell fields, are differentially involved in behavior.
为了研究不同海马细胞区的结构和功能，设计了一种手术方法，该方法允许选择性损伤海马亚区或主要传出投射。实验1中使用神经解剖学技术来验证损伤的选择性，并提供有关海马不同投射的信息。在实验2中，对患有选择性海马损伤的大鼠进行了一系列旨在测量行为各个方面的任务测试。海马伞损伤中断了CA3 - CA4细胞区与隔区之间连接的动物，与海马广泛损伤的动物相似，在夜间比其他组更活跃，白天更活跃，并且受剥夺的影响更大。此外，两组在穿梭箱回避任务的习得方面都得到了促进。海马的广泛损伤和对CA1锥体细胞区的更选择性损伤导致空间反转学习受损。这些结果被解释为支持以下观点：海马的两个主要亚区，即CA1和CA3 - CA4细胞区，在行为中发挥不同的作用。
