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Distinct clonal origin of low-grade MALT-type and high-grade lesions of a multifocal gastric lymphoma.

作者信息

Matolcsy A, Nagy M, Kisfaludy N, Kelényi G

机构信息

Department of Pathology, University Medical School of Pécs, Hungary.

出版信息

Histopathology. 1999 Jan;34(1):6-8. doi: 10.1046/j.1365-2559.1999.00568.x.

DOI:10.1046/j.1365-2559.1999.00568.x
PMID:9934578
Abstract

AIMS

Low-grade mucosa-associated lymphoid tissue (MALT) lymphoma and high-grade B-cell non-Hodgkin's lymphoma (NHL) of the stomach may occur simultaneously. To determine the clonal relationship between these tumours, we compared the immunoglobulin heavy chain gene (IgH) rearrangements of low and high-grade components of a multifocal gastric NHL.

METHODS AND RESULTS

The complementary determining region 3 (CDR3) of the IgH gene rearrangements were polymerase chain reaction (PCR) amplified, cloned and sequenced. The analysis of the CDR3 sequences rearranged by tumour cells of low-grade MALT and the high-grade NHL revealed different nucleic acid sequences.

CONCLUSION

These findings suggest that low-grade MALT and high-grade B-cell components of multifocal gastric NHL may represent unrelated clones.

摘要

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