Cetinkaya M, Günçe S, Ulusoy E, Aksoy F, Yildiz O, Adsan O, Ozden C
Department of Urology, Ankara Numune Hospital, Turkey.
Int Urol Nephrol. 1998;30(5):581-5. doi: 10.1007/BF02550549.
The aim of this study was to investigate the relationship between prostate specific antigen density and prostate volume with microvessel density in patients with benign prostatic hyperplasia and advanced prostatic carcinoma. Sixty-eight patients with benign prostatic hyperplasia and 11 patients with advanced prostatic carcinoma participated in the study. The paraffin blocks of all patients were stained with CD34 by the standard immunohistochemical technique and microvessel density, prostate specific antigen density and prostatic volume were determined. In patients with benign prostatic hyperplasia the mean microvessel density, mean prostate specific antigen density and mean prostatic volume were 74+/-89+/-22.73, 0.12+/-0.10 and 59.97+/-27.0 ml, respectively. There was no correlation between prostate specific antigen density and mean prostatic volume or microvessel density (r = 0.079 and -0.095, respectively). In patients with advanced prostatic carcinoma the mean microvessel density, mean prostate specific antigen density and mean prostatic volume were 147.90+/-47.55, 0.63+/-0.41 and 54.00+/-22.42 ml, respectively. In this group, while there was a good correlation between prostate specific antigen density and microvessel density (r = 0.785), no significant correlation was found between prostatic volume and microvessel density (r = -0.07). There was significant statistical difference in patients with advanced prostatic carcinoma compared to patients with benign prostatic hyperplasia in terms of mean microvessel density (p<0.0001). The findings that there was no correlation between prostatic volume and MVD either in benign prostatic hyperplasia or in prostatic carcinoma suggest that microvessel development is not correlated with prostatic volume but may be correlated with morphology.
本研究旨在探讨良性前列腺增生症和晚期前列腺癌患者的前列腺特异性抗原密度、前列腺体积与微血管密度之间的关系。68例良性前列腺增生症患者和11例晚期前列腺癌患者参与了本研究。采用标准免疫组织化学技术对所有患者的石蜡块进行CD34染色，并测定微血管密度、前列腺特异性抗原密度和前列腺体积。良性前列腺增生症患者的平均微血管密度、平均前列腺特异性抗原密度和平均前列腺体积分别为74±89±22.73、0.12±0.10和59.97±27.0 ml。前列腺特异性抗原密度与平均前列腺体积或微血管密度之间无相关性（r分别为0.079和-0.095）。晚期前列腺癌患者的平均微血管密度、平均前列腺特异性抗原密度和平均前列腺体积分别为147.90±47.55、0.63±0.41和54.00±22.42 ml。在该组中，前列腺特异性抗原密度与微血管密度之间存在良好的相关性（r = 0.785），而前列腺体积与微血管密度之间未发现显著相关性（r = -0.07）。晚期前列腺癌患者与良性前列腺增生症患者相比，平均微血管密度存在显著统计学差异（p<0.0001）。良性前列腺增生症和前列腺癌患者的前列腺体积与微血管密度均无相关性，这一发现表明微血管发育与前列腺体积无关，但可能与形态有关。
