Sato Y, Tsukada K, Hatakeyama K
First Department of Surgery, Niigata University School of Medicine, Japan.
Surg Today. 1999;29(1):1-9. doi: 10.1007/BF02482962.
This report reviews studies addressing the new concepts in liver regeneration after a partial hepatectomy (PHx). The review begins with an overview of the immunologic mechanisms of liver regeneration after PHx, especially regarding Kupffer cells and extrathymic T cells of the regenerative liver in the cell-mediated immunity, based on major histocompatibility complex I and II antigens. Attention is then devoted to "on and off" studies in liver regeneration after PHx, by hypothesizing the shear stress based on the fact that the portal flow against hepatocytes or sinusoidal endothelial cells triggers their regeneration after a partial hepatectomy and controls the volume of the regenerating liver by the stimulating the cell surface modulator (CSM) of hepatocytes and sinusoidal endothelial cells (SEC). We propose that the acute elevation of shear stress after PHx influences the adhesion between SEC and intrahepatic leukocytes. These concepts are expected to positively contribute to the future research on liver regeneration after PHx.
本报告回顾了关于部分肝切除术后肝脏再生新概念的研究。综述首先概述了部分肝切除术后肝脏再生的免疫机制，特别是基于主要组织相容性复合体I和II抗原，在细胞介导免疫中关于库普弗细胞和再生肝脏的胸腺外T细胞。接着，基于部分肝切除术后门静脉血流对抗肝细胞或窦状内皮细胞会触发其再生，并通过刺激肝细胞和窦状内皮细胞（SEC）的细胞表面调节剂（CSM）来控制再生肝脏体积这一事实，通过假设剪切应力，关注部分肝切除术后肝脏再生的“开启和关闭”研究。我们提出，部分肝切除术后剪切应力的急性升高会影响SEC与肝内白细胞之间的黏附。这些概念有望对未来部分肝切除术后肝脏再生的研究做出积极贡献。
