Roux C, Desmont G, Mulliez N, Gaulier M, Tufferaud G, Marmor D, Herbillon A
J Gynecol Obstet Biol Reprod (Paris). 1976 Mar;5(2):249-64.
The authors report the results of prophylaxis of congenital toxoplasmosis in a maternity hospital in Paris for a two years period (1973-1974). 6269 pregnant women were surveyed. 18 toxoplasmosis were detected in evolution at the first prenatal examination, 10 seroconversions were identified among the first examination antibody negative women, when re-examined during the pregnancy. 25 of these 28 women were treated regularly. The seroconversions of the 3 other women were detected only at delivery. In addition 25 women were treated because of high antibody titers (Dye-Test greater than or equal to 300. U.I/ml). 6 congenital toxoplasmosis, 2 of them were manifest, were observed among the children whose mothers were treated for confirmed toxoplasmosis. The extremely low level of seroconversions may be in relation to hygienic and dietetic prescriptions. The difficulties of this prophylaxis are analysed: they are due to studied population and to problems of interpretation or serologic examinations.
作者报告了巴黎一家妇产医院在两年期间（1973 - 1974年）先天性弓形虫病的预防结果。对6269名孕妇进行了调查。在首次产前检查时发现18例正在发展的弓形虫病，在首次检查抗体阴性的孕妇中，孕期复查时发现10例血清学转换。这28名妇女中有25名接受了正规治疗。另外3名妇女的血清学转换仅在分娩时才被检测到。此外，25名妇女因抗体效价高（染料试验大于或等于300 U.I/ml）而接受治疗。在其母亲因确诊弓形虫病而接受治疗的儿童中，观察到6例先天性弓形虫病，其中2例有临床表现。血清学转换水平极低可能与卫生和饮食规定有关。分析了这种预防措施的困难：它们归因于研究人群以及血清学检查的解释问题。
