取代苯胺基-3-甲氧基-4-取代乙酰氧基）亚苄基的合成及其单胺氧化酶抑制和抗惊厥特性。
Synthesis of substituted anilino-3-methoxy-4-substituted acetoxy) benzylidenes and their monoamine oxidase inhibitory and anticonvulsant properties.
作者信息
Singh S P, Chaudhari A, Stenberg V I, Parmar S S
出版信息
J Pharm Sci. 1976 Nov;65(11):1678-81. doi: 10.1002/jps.2600651128.
PMID:994001
Abstract
Several substituted anilino-(3-methoxy-4-substituted acetoxy) benzylidenes were synthesized and characterized by their sharp melting points and elemental analyses. All substituted benzylidenes competitively inhibited the in vitro monoamine oxidase activity of rat brain homogenates and possessed anticonvulsant activity against pentylenetetrazol-induced convulsions in mice.
摘要
合成了几种取代苯胺基 -（3 - 甲氧基 - 4 - 取代乙酰氧基）亚苄基化合物，并通过其敏锐的熔点和元素分析对其进行了表征。所有取代亚苄基化合物均能竞争性抑制大鼠脑匀浆的体外单胺氧化酶活性，并对小鼠戊四氮诱导的惊厥具有抗惊厥活性。
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