Hirata T, Driscoll J S
J Pharm Sci. 1976 Nov;65(11):1699-701. doi: 10.1002/jps.2600651136.
Four phenothiazine derivatives containing the bis(beta-chloroethyl)aminopropyl side chain were prepared and evaluated in the murine L-1210, P-388, and B-16 melanoma intraperitoneal tumor systems. Moderate P-388 activity was observed. An aminoethyl phenothiazine mustard was compared with the aminopropyl analogs and was superior in all test systems. None of the compounds tested against the murine ependymoblastoma brain tumor system was active.
制备了四种含有双（β-氯乙基）氨基丙基侧链的吩噻嗪衍生物，并在小鼠L-1210、P-388和B-16黑色素瘤腹腔肿瘤系统中进行了评估。观察到中等的P-388活性。将一种氨基乙基吩噻嗪氮芥与氨基丙基类似物进行了比较，在所有测试系统中前者更具优势。在针对小鼠室管膜母细胞瘤脑肿瘤系统测试的化合物中，无一具有活性。
