• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过在水性表面活性剂溶液中结晶提高难溶性药物的溶出速率I：磺胺噻唑、泼尼松和氯霉素。

Enhancement of dissolution rates of poorly water-soluble drugs by crystallization in aqueous surfactant solutions I: Sulfathiazole, prednisone, and chloramphenicol.

作者信息

Chiou W L, Chen S J, Athanikar N

出版信息

J Pharm Sci. 1976 Nov;65(11):1702-4. doi: 10.1002/jps.2600651137.

DOI:10.1002/jps.2600651137
PMID:994008
Abstract

Effects of crystallization of poorly water-soluble drugs in aqueous surfactant solution on in vitro dissolution rates were investigated. Marked enhancement was observed for chloramphenicol, sulfathiazole, and prednisone. Differential thermal analysis studies indicated the presence of small amounts of surfactant in surfactant-treated crystals. Possible mechanisms of dissolution enhancement are discussed.

摘要

研究了难溶性药物在水性表面活性剂溶液中的结晶对体外溶出速率的影响。观察到氯霉素、磺胺噻唑和泼尼松有显著增强。差示热分析研究表明，经表面活性剂处理的晶体中存在少量表面活性剂。讨论了溶出增强的可能机制。

相似文献

1
Enhancement of dissolution rates of poorly water-soluble drugs by crystallization in aqueous surfactant solutions I: Sulfathiazole, prednisone, and chloramphenicol.通过在水性表面活性剂溶液中结晶提高难溶性药物的溶出速率I：磺胺噻唑、泼尼松和氯霉素。
J Pharm Sci. 1976 Nov;65(11):1702-4. doi: 10.1002/jps.2600651137.
2
A study of some factors affecting the dissolution rate enhancement of sulfamethoxazole by crystallization in aqueous surfactant solutions.关于一些影响在水性表面活性剂溶液中通过结晶提高磺胺甲恶唑溶解速率的因素的研究。
Pharmazie. 1986 Nov;41(11):787-9.
3
Dissolution rates of high energy sulfathiazole--povidone coprecipitates II: characterization of form of drug controlling its dissolution rate via solubility studies.高能磺胺噻唑-聚维酮共沉淀物的溶出速率II：通过溶解度研究表征控制其溶出速率的药物形式
J Pharm Sci. 1976 Mar;65(3):355-61. doi: 10.1002/jps.2600650310.
4
Particle design of tolbutamide in the presence of soluble polymer or surfactant by the spherical crystallization technique: improvement of dissolution rate.通过球形结晶技术在可溶性聚合物或表面活性剂存在下制备甲苯磺丁脲的颗粒设计：提高溶解速率。
J Pharm Sci. 1987 Jun;76(6):471-4. doi: 10.1002/jps.2600760612.
5
The effects of surfactants on the dissolution profiles of poorly water-soluble acidic drugs.表面活性剂对难溶性酸性药物溶出曲线的影响。
Int J Pharm. 2006 Sep 14;321(1-2):35-41. doi: 10.1016/j.ijpharm.2006.05.004. Epub 2006 May 9.
6
STUDIES ON THE MOLECULAR COMPOUNDS OF ORGANIC MEDICINALS. I. DISSOLUTION BEHAVIOR OF THE MOLECULAR COMPOUNDS OF SULFANILAMIDE AND SULFATHIAZOLE.
Chem Pharm Bull (Tokyo). 1965 Apr;13:405-13. doi: 10.1248/cpb.13.405.
7
A mechanistic study of griseofulvin dissolution into surfactant solutions under laminar flow conditions.在层流条件下灰黄霉素在表面活性剂溶液中溶解的机理研究。
J Pharm Sci. 1997 Oct;86(10):1132-7. doi: 10.1021/js9604974.
8
Antisolvent precipitation technique: A very promising approach to crystallize curcumin in presence of polyvinyl pyrrolidon for solubility and dissolution enhancement.反溶剂沉淀技术：一种很有前途的方法，可在聚乙烯吡咯烷酮存在下结晶姜黄素，以提高其溶解度和溶解性能。
Colloids Surf B Biointerfaces. 2016 Nov 1;147:258-264. doi: 10.1016/j.colsurfb.2016.08.004. Epub 2016 Aug 6.
9
In situ controlled crystallization as a tool to improve the dissolution of Glibenclamide.原位控制结晶作为提高格列本脲溶解性能的一种手段。
Int J Pharm. 2012 May 30;428(1-2):118-20. doi: 10.1016/j.ijpharm.2012.02.046. Epub 2012 Mar 7.
10
To evaluate the change in release from solid dispersion using sodium lauryl sulfate and model drug sulfathiazole.评估使用十二烷基硫酸钠和模型药物磺胺噻唑的固体分散体的释放变化。
Drug Dev Ind Pharm. 2013 Oct;39(10):1562-72. doi: 10.3109/03639045.2012.725731. Epub 2012 Oct 3.

引用本文的文献

1
Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): development and optimization.依西美坦自微乳化药物递送系统（SMEDDS）：研发与优化
AAPS PharmSciTech. 2008;9(2):628-34. doi: 10.1208/s12249-008-9080-6. Epub 2008 May 13.
2
Development of prednisone:polyethylene glycol 6000 fast-release tablets from solid dispersions: solid-state characterization, dissolution behavior, and formulation parameters.泼尼松：聚乙二醇6000速释片固体分散体的研制：固态表征、溶出行为及处方参数
AAPS PharmSciTech. 2007 Dec 14;8(4):E108. doi: 10.1208/pt0804108.
3
Effects of surfactants on amiodarone intestinal absorption. I. Sodium laurylsulfate.
表面活性剂对胺碘酮肠道吸收的影响。I. 十二烷基硫酸钠。
Pharm Res. 1994 Jul;11(7):1042-7. doi: 10.1023/a:1018947723406.
4
The influence of the crystallization on the properties of a hydrophobic drug.
Pharm Weekbl Sci. 1982 Feb 19;4(1):5-11. doi: 10.1007/BF02112350.