Thomsen K
J Pharmacol Exp Ther. 1976 Dec;199(3):483-9.
The relation between urine flow (V), lithium clearance (CLi) and sodium clearance (CNa) was studied in rats given food containing lithium in amounts leading to inhibition of distal reabsorption of water and sodium. Maximum inhibition of the reabsorption of water was reached at serum lithium concentrations of about 1 mM. At higher serum lithium levels the rats developed intoxication due to a lowering of CLi and a consequent rise of the serum lithium concentration. The intoxication was characterized by a proportional decrease of V and CLi. The decrease of V and CLi was not related to changes of CNa. The results indicate that lithium is reabsorbed in the proximal tubules in parallel with sodium and that the lowering of CLi is due to increased fractional proximal reabsorption of lithium and sodium compensatory to inhibition of the distal reabsorption of sodium.
在给大鼠喂食含锂食物致使远曲小管对水和钠的重吸收受到抑制的情况下，研究了尿流率（V）、锂清除率（CLi）与钠清除率（CNa）之间的关系。当血清锂浓度约为1 mM时，水重吸收的抑制作用达到最大。在更高的血清锂水平时，大鼠因CLi降低以及随之而来的血清锂浓度升高而出现中毒症状。中毒的特征是V和CLi成比例下降。V和CLi的下降与CNa的变化无关。结果表明，锂在近端小管中与钠平行重吸收，且CLi降低是由于锂和钠的近端重吸收分数增加，以代偿远曲小管对钠重吸收的抑制。
