Hufnagel C A, Gomes M N
J Thorac Cardiovasc Surg. 1976 Dec;72(6):900-9.
Clincal and hemodynamic observations are reported in a group of five patients with free aortic regurgitation treated with insertion of a ball valve prosthesis in the descending aorta. Long-term follow-up ranging from 13 to 23 years illustrates the durability and biocompatibility of the valve and the validity of the concept that a moving prosthesis can function for indefinitely long periods of time. The prolonged survival of these patients at a normal level of activity without congestive failure is strong evidence of the efficacy of the prosthesis even though it did not entirely control all of the aortic insufficiency. All patients showed remarkable improvement of their symptoms from 11 to 21 years after surgery. Four of them have required complete correction of the aortic insufficiency with one postoperative death due to low output syndrome. The valves which have remained in place after insertion of a subcoronary valve are functioning well for 3 to 6 years. There was no evidence of hemolysis, valve malfunction, ball variance, or thrombbosis in any of these patients. The evolution of the technique made it possible to minimize complications which, it should be pointed out, were usually associated with faulty methods of insertion. These patients would appear to represent the longest period of insertion of any valvular prosthesis.
报告了一组五例主动脉瓣反流患者，通过在降主动脉植入球瓣假体进行治疗的临床和血流动力学观察结果。长达13至23年的长期随访表明了该瓣膜的耐用性和生物相容性，以及可移动假体能够无限期发挥功能这一概念的有效性。这些患者在正常活动水平下长期存活且无充血性心力衰竭，有力地证明了该假体的有效性，尽管它并未完全控制所有的主动脉瓣关闭不全。所有患者术后11至21年症状均有显著改善。其中四人需要对主动脉瓣关闭不全进行完全纠正，有一例术后因低心排血量综合征死亡。植入冠状动脉下瓣膜后仍在位的瓣膜已良好运行3至6年。这些患者中均未发现溶血、瓣膜功能障碍、球瓣变异或血栓形成的证据。技术的发展使得并发症得以尽量减少，应当指出的是，这些并发症通常与错误的植入方法有关。这些患者似乎代表了任何瓣膜假体植入后的最长时间。
