Thomson T A, Horsman D, Bainbridge T C
Department of Laboratory Medicine, British Columbia Cancer Agency, Vancouver Clinic, Canada.
Mod Pathol. 1999 Jan;12(1):88-91.
The cytologic and cytogenetic findings of chondroid lipoma, a rare benign tumor of soft tissue, have not been described. This report details the morphologic features of a fine-needle aspiration biopsy specimen and describes a novel cytogenetic finding. The main cytologic features consisted of clustered, variably mature, multivacuolated, hibernoma-like cells enmeshed in a capillary plexus, with a background of chondromyxoid material. Cytogenetic analysis revealed a balanced translocation t (11, 16)(q13;p12-13) distinct from the known translocation involving 16p11 in myxoid and round-cell liposarcoma. The 11q13 breakpoint was previously noted in hibernomas, raising the possibility of a common genetic deregulation.
软骨样脂肪瘤是一种罕见的软组织良性肿瘤，其细胞学和细胞遗传学特征尚未见报道。本报告详细描述了细针穿刺活检标本的形态学特征，并描述了一项新的细胞遗传学发现。主要细胞学特征为成簇的、成熟程度不一的、多空泡的、冬眠瘤样细胞，包埋于毛细血管丛中，背景为软骨黏液样物质。细胞遗传学分析显示一种平衡易位t(11;16)(q13;p12 - 13)，不同于黏液样和圆形细胞脂肪肉瘤中已知的涉及16p11的易位。11q13断点先前在冬眠瘤中已被发现，提示可能存在共同的基因失调。
